Structural properties of functional groups which produce class III antiarrhythmic action

Structural Properties of Inner Amenable Discrete Groups

Effects of sematilide, a novel class III antiarrhythmic agent, on action potential in guinea pig atrium.

Electrophysiological effects of sematilide, a novel class III antiarrhythmic agent, were examined and compared with those of (+/-)sotalol in guinea pig left atrium by a conventional microelectrode technique. Application of 0.1-1000 microM sematilide or 1-1000 microM (+/-)sotalol concentration-dependently prolonged the duration of action potentials (APD) that were elicited by electrical stimulat...

Class III antiarrhythmic methanesulfonanilides inhibit leukocyte recruitment in zebrafish.

Understanding fundamental molecular mechanisms that govern the transmigration and interstitial migration of leukocytes to sites of tissue damage and infection is of potential significance in identifying novel therapeutic targets for the management of chronic inflammatory disorders. CD31 is a mammalian cell adhesion molecule that regulates the recruitment of leukocytes from the circulation. Our ...

Galois Action on Class Groups

It is well known that the Galois group of an extension L/F puts constraints on the structure of the relative ideal class group Cl(L/F ). Explicit results, however, hardly ever go beyond the semisimple abelian case, where L/F is abelian (in general cyclic) and where (L : F ) and #Cl(L/F ) are coprime. Using only basic parts of the theory of group representations, we give a unified approach to th...

Mechanisms of termination of reentrant atrial arrhythmias by class I and class III antiarrhythmic agents.

We studied atrial flutter due to circus movement in chronically instrumented conscious dogs to identify the mechanism by which class I and class III antiarrhythmic drugs terminate reentrant excitation. We used a crossover experimental design administering five class I agents and one class III agent, by intravenous bolus followed by intravenous infusion. The class I agents other than lidocaine w...